ABSTRACT
Objective:To evaluate the efficacy of low-dose radiotherapy in patients with advanced hypopharyngeal cancer without high-risk factors.Methods:Clinical data of 235 patients diagnosed with advanced hypopharyngeal cancer treated in Department of Head and Neck Surgery of Shandong Provincial ENT Hospital from December 2013 to August 2018 were retrospectively analyzed. All patients were divided into two groups: low-dose radiotherapy group (50 Gy, n=158) and high-dose radiotherapy group (>60 Gy, n=77). Clinical baseline characteristics, treatment, follow-up and survival of patients were collected. Survival curve was delineated using the Kaplan-Meier method, and the differences in survival between two groups were calculated using the log-rank test. Clinical baseline characteristics between two groups were compared by χ2 test. Univariate and multivariate analyses of prognostic factors were conducted by logistic regression model. Results:The median follow-up time was 45 months (5-94 months). The 3-year overall survival (OS) rate of the whole group was 68.5%, and 70.3% and 64.9% in the low-dose and high-dose groups, respectively ( P=0.356). The 3-year progression-free survival (PFS) rate of the whole group was 64.3%, and 65.8% and 61.0% in the low-dose and high-dose groups, respectively ( P=0.361). Univariate analysis showed that T stage, N stage, lesion location and degree of pathological differentiation significantly affected clinical prognosis (all P<0.05), whereas there was no significant relationship between age, sex, radiotherapy dose, interval between surgery and radiotherapy and survival. Multivariate analysis showed that T stage, N stage and the degree of pathological differentiation were the independent prognostic factors (all P<0.05) of the 3-year OS and PFS. Sex, radiotherapy dose and interval between surgery and radiotherapy were not correlated with OS and PFS. Conclusion:This study showed that for hypopharyngeal cancer patients without positive surgical margins and extracapsular extension, postoperative radiotherapy at a dose of 50 Gy given to tumor bed and selective lymph node drainage area does not compromise local disease control and OS.
ABSTRACT
Heterogeneity is one of the important features of malignant tumors.MRI texture analysis (MTA) is a new imaging post-processing technique to quantify heterogeneity of tumor.Increasing number of studies have shown that MTA is a potentially useful tool in tumor imaging,and can provide important and valuable information including tumor characteristics,prognosis assessment,prediction or monitoring of tumor treatment response,and so on.In this article,we review the literatures about MTA in evaluating heterogeneity of tumor.The correlation between MTA and tumor response to chemotherapy,prognosis and survival time,and the role of MTA as imaging markers in clinical practice are summarized,to further explore its potential in clinical application.
ABSTRACT
Heterogeneity is one of the important features of malignant tumors.MRI texture analysis (MTA) is a new imaging post-processing technique to quantify heterogeneity of tumor.Increasing number of studies have shown that MTA is a potentially useful tool in tumor imaging,and can provide important and valuable information including tumor characteristics,prognosis assessment,prediction or monitoring of tumor treatment response,and so on.In this article,we review the literatures about MTA in evaluating heterogeneity of tumor.The correlation between MTA and tumor response to chemotherapy,prognosis and survival time,and the role of MTA as imaging markers in clinical practice are summarized,to further explore its potential in clinical application.
ABSTRACT
The most of extranodal nasal type NK/ T-cell lymphoma(ENKTL)are in the Ⅰ/ Ⅱ stage. Radiotherapy alone is insufficient to achieve a high cure rate for the early stage patients with ENKTL due to fre-quent local and systemic relapse. Concomitant/ sequential chemotherapy and radiotherapy is the standard treat-ment for the early stage patients with ENKTL. For the patients with stage Ⅲ/ Ⅳ ENKTL,regimens containing L-asparaginase are most effective. For the patients with advanced stage ENKTL or refractory recurrent ENKTL, hematopoietic stem cell transplantation may be considered when the remission is achieved.